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Discrimination of Prostate Cancer from Normal Peripheral Zone and Central Gland Tissue by Using Dynamic Contrast-enhanced MR Imaging¹

¹ From the Departments of Radiology (M.R.E., H.J.H., G.J.J., J.G.B., J.O.B.), Epidemiology and Biostatistics (R.J.F.L.), Pathology (G.J.L.H.v.L., C.A.H.V.D.K.), and Urology (J.J.M.C.H.d.l.R.), University Medical Center Nijmegen, PO Box 9101, NL 6500 HB, Nijmegen, the Netherlands. From the 2001 RSNA scientific assembly. Received March 10, 2002; revision requested May 8; final revision received January 21, 2003; accepted February 21. Supported by the Dutch Cancer Society. Address correspondence to M.R.E. (e-mail: m.engelbrecht@rad.umcn.nl).

View larger version (44K): [in a new window]   Mean (± SD) of carcinoma () compared with normal tissue () in the prostate. Each carcinoma site is represented as a separate case. c = scaling factor, mmol Gd-DTPA/kg = mmol/kg gadopentetate dimeglumine. A, Relative peak enhancement in the PZ (32 separate carcinoma sites). Carcinoma demonstrates a higher relative peak enhancement than does normal tissue. One carcinoma site (arrowhead) demonstrates a lower relative peak enhancement than does normal tissue. In this case, severe coexistent chronic active prostatitis was present throughout the prostate. Interpatient variation is present (eg, carcinoma sites 2 versus 32 [arrows]). B, Relative peak enhancement in the CG (23 separate carcinoma sites). In general, carcinoma demonstrates a higher relative peak enhancement than does normal tissue. Carcinoma sites 5 and 12 (arrows) demonstrate a lower relative peak enhancement than does normal tissue. No histologic differences were noted between the prostate glands of these patients (sites 5 and 12) and those of other patients. C, Washout in the CG (23 separate carcinoma sites). In general, carcinoma demonstrates washout, whereas normal tissue does not. Carcinoma site 12 (arrow) shows false-positive washout. No histologic differences were noted between the prostate gland of this patient and the prostate glands of other patients.