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Quantification of Bone Involvement in Gaucher Disease: MR Imaging Bone Marrow Burden Score as an Alternative to Dixon Quantitative Chemical Shift MR Imaging—Initial Experience¹

¹ From the Departments of Radiology (M.M., C.v.K., J.S., E.M.A., G.J.d.H.), Hematology (C.E.M.H.), and Biochemistry (J.F.M.G.A.), Academic Medical Center, Meibergdreef 9, Suite G1–231, 1105 AZ Amsterdam, the Netherlands. Received April 17, 2002; revision requested July 8; final revision received March 13, 2003; accepted April 7. Address correspondence to M.M. (e-mail: m.maas@amc.uva.nl).

View larger version (125K): [in a new window]   Figure 1a. Coronal (a) T1- and (b) T2-weighted MR images of femora. There is only a slight decrease in signal intensity in the femoral metaphysis and diaphysis. The epiphysis shows no involvement.

View larger version (120K): [in a new window]   Figure 1b. Coronal (a) T1- and (b) T2-weighted MR images of femora. There is only a slight decrease in signal intensity in the femoral metaphysis and diaphysis. The epiphysis shows no involvement.

View larger version (112K): [in a new window]   Figure 2a. Coronal (a) T1- and (b) T2-weighted MR images of the femora in another patient. The left femur has low signal intensity on the T1-weighted image (a) and is an example of a mixed pattern, which is particularly present on the T2-weighted image (b).

View larger version (119K): [in a new window]   Figure 2b. Coronal (a) T1- and (b) T2-weighted MR images of the femora in another patient. The left femur has low signal intensity on the T1-weighted image (a) and is an example of a mixed pattern, which is particularly present on the T2-weighted image (b).

View larger version (85K): [in a new window]   Figure 3a. Sagittal (a) T1- and (b) T2-weighted MR images of the lumbar spine obtained in the same patient as in Figure 1. The lumbar spine shows more infiltration than the femora. There is marked low signal intensity on both T1- and T2-weighted images. The preservation of the fat surrounding the basivertebral vein is clearly appreciable.

View larger version (91K): [in a new window]   Figure 3b. Sagittal (a) T1- and (b) T2-weighted MR images of the lumbar spine obtained in the same patient as in Figure 1. The lumbar spine shows more infiltration than the femora. There is marked low signal intensity on both T1- and T2-weighted images. The preservation of the fat surrounding the basivertebral vein is clearly appreciable.

View larger version (90K): [in a new window]   Figure 4a. Sagittal (a) T1- and (b) T2-weighted MR images of the lumbar spine in another patient. There is diffuse infiltration of the axial bone marrow seen on both a and b, reflecting severe involvement.

View larger version (98K): [in a new window]   Figure 4b. Sagittal (a) T1- and (b) T2-weighted MR images of the lumbar spine in another patient. There is diffuse infiltration of the axial bone marrow seen on both a and b, reflecting severe involvement.

View larger version (17K): [in a new window]   Figure 5. Graph shows correlation in BMB score between two observers ( = 0.91, P < .001).

View larger version (17K): [in a new window]   Figure 6. Graph shows relation between fat fraction and BMB scoring in untreated patients ( = -0.78, P < .001).