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Published online before print July 23, 2004, 10.1148/radiol.2323031224
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Stereotactic 11-gauge Vacuum-assisted Breast Biopsy: Influence of Number of Specimens on Diagnostic Accuracy1

Friedrich M. Lomoschitz, MD, Thomas H. Helbich, MD, Margarete Rudas, MD, Georg Pfarl, MD, Ken F. Linnau, MD, Alfred Stadler, MD and Roger J. Jackman, MD

1 From the Departments of Radiology (F.M.L., T.H.H., G.P., K.F.L., A.S.) and Pathology (M.R.), University of Vienna Medical School, AKH Wien, Waehringer Guertel 18–20, A-1090 Vienna, Austria; Ludwig Boltzmann Institute for Clinical and Experimental Radiology Research, Vienna, Austria (F.M.L., T.H.H., G.P., K.F.L., A.S.); and Department of Radiology, Palo Alto Medical Clinic, Palo Alto, Calif (R.J.J.). From the 2000 RSNA scientific assembly. Received August 1, 2003; revision requested October 15; final revision received December 5; accepted January 13, 2004. Address correspondence to F.M.L. (e-mail: friedrich .lomoschitz@univie.ac.at).



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  		Bar graph illustrates diagnostic yield for four measures of histologic accuracy from progressive number of stereotactic 11-gauge VABB tissue specimens obtained with patients lying prone. Graph shows comparison of mammographic appearance in 50 lesions that appeared as masses (white bars) and 50 that appeared as microcalcifications (gray bars). Specimens 1-6, 7-12, and 13-20 represent the first, second, and third 360° probe rotations, respectively, with individual histopathologic assessment of specimens 1-6 and pooled histopathologic assessment of specimens 7-12 and 13-20. For lesions that appeared as masses and microcalcifications, the increase in diagnostic yield was for up to 12 specimens per lesion but not for more than 12 specimens per lesion. Comparison of diagnostic yield for lesions with appearances as masses and microcalcifications revealed a statistically significant difference with two specimens (P = .04) but no statistically significant difference with one (P = .17) or more than two specimens (specimen 3 [P = .18], 4 [P = .08], 5 [P = .1], 6 [P = .5], 7-12 [P = .68], and 13-20 [P = .68]).

 




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