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DOI: 10.1148/radiol.2343031084
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1/T2 and Magnetic Susceptibility Measurements in a Gerbil Cardiac Iron Overload Model1

Zhiyue J. Wang, PhD, Lurong Lian, MD, Qiukan Chen, MD, Huaqing Zhao, MA, Toshio Asakura, MD and Alan R. Cohen, MD

1 From the Department of Radiology (Z.J.W.), Divisions of Hematology (L.L., Q.C., T.A., A.R.C.) and Biostatistics and Epidemiology (H.Z.), Department of Pediatrics, Children’s Hospital of Philadelphia, Pa. Received July 10, 2003; revision requested September 25; final revision received June 3, 2004; accepted June 23. Supported by NIH grant R01 HL61182. Address correspondence to Z.J.W., Department of Diagnostic Imaging, Texas Children’s Hospital, Department of Radiology, Baylor College of Medicine, 6621 Fannin St, MC2 2521, Houston, TX 77030 (e-mail: zjwang@bcm.tmc.edu).



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  		Figure 1. Curves for signal intensity versus TE from ex vivo MR imaging in two gerbil hearts with iron concentrations of 0.28 ({square}) and 1.72 ({triangleup}) mg Fe/g wet tissue. TR was 700 msec in both cases. Lines were fit with single-exponential decay functions.

 


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  		Figure 2. Scatterplot shows correlation between 1/T2 (TR = 700 msec) and heart iron concentration. Solid line is linear regression line given by –0.834 + 0.0344/T2 (Pearson correlation, r = 0.92, P < .001).

 


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  		Figure 3. Phase map from MR measurements in tissue lysate from two gerbils, with background water used as reference. B0 is along the vertical direction. Phase jumps at the boundaries (arrows) are quantified for magnetic susceptibility measurement.

 


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  		Figure 4. Scatterplot shows correlation between {Delta}{chi} (difference in magnetic susceptibility of cardiac tissue and water) and tissue iron concentration. Solid line is linear regression line given by 0.343 + 6.25 x 105 · {Delta}{chi} (Pearson correlation, r = 0.90, P < .001).

 


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  		Figure 5. Scatterplot shows correlation between 1/T2 (average for the three TRs) and {Delta}{chi} (difference in magnetic susceptibility between cardiac tissue and water). Solid line is linear regression line given by 36.6 + 1.55 x 107 · {Delta}{chi} (Pearson correlation, r = 0.90, P < .001).

 




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