HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Abstract Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lu, D. S. K. Articles by Busuttil, R. W. Search for Related Content PubMed PubMed Citation Articles by Lu, D. S. K. Articles by Busuttil, R. W.

Radiofrequency Ablation of Hepatocellular Carcinoma: Treatment Success as Defined by Histologic Examination of the Explanted Liver¹

¹ From the Departments of Radiology (D.S.K.L., N.C.Y., S.S.R., P.L.), Pathology (C.L., K.M.), Medicine (M.J.T., R.G.A.), and Surgery (R.W.B.), UCLA School of Medicine, 10833 LeConte Ave, Los Angeles, CA 90095-1721. From the 2003 RSNA Annual Meeting. Received January 26, 2004; revision requested April 6; revision received June 9; accepted July 20. Address correspondence to D.S.K.L.

View larger version (147K): [in a new window]   Figure a. Images of a 33-year-old man with chronic hepatitis B. (a) Contrast-enhanced transverse spoiled gradient-recalled-echo MR image obtained before ablation shows two hypervascular lesions in segments V (black arrow) and VI (white arrow). (b) Contrast-enhanced transverse CT image obtained 3 weeks after ablation shows hypoattenuating, nonenhancing coagulation defects at the treatment sites (arrows) with no abnormal nodular enhancement suggesting residual tumor. (c) Histologic slice (hematoxylin-eosin stain; original magnification, x400) of tumor in segment VI demonstrates complete necrosis, marked by homogeneous hypereosinophilic cytoplasm and loss of normal nuclear elements. (d) Histologic slice (hematoxylin-eosin stain; original magnification, x20) of lesion in segment V shows necrotic areas (*) with bordering regions of viable-appearing tumor to the right. Viability was confirmed with findings from higher magnification.

View larger version (157K): [in a new window]   Figure b. Images of a 33-year-old man with chronic hepatitis B. (a) Contrast-enhanced transverse spoiled gradient-recalled-echo MR image obtained before ablation shows two hypervascular lesions in segments V (black arrow) and VI (white arrow). (b) Contrast-enhanced transverse CT image obtained 3 weeks after ablation shows hypoattenuating, nonenhancing coagulation defects at the treatment sites (arrows) with no abnormal nodular enhancement suggesting residual tumor. (c) Histologic slice (hematoxylin-eosin stain; original magnification, x400) of tumor in segment VI demonstrates complete necrosis, marked by homogeneous hypereosinophilic cytoplasm and loss of normal nuclear elements. (d) Histologic slice (hematoxylin-eosin stain; original magnification, x20) of lesion in segment V shows necrotic areas (*) with bordering regions of viable-appearing tumor to the right. Viability was confirmed with findings from higher magnification.

View larger version (180K): [in a new window]   Figure c. Images of a 33-year-old man with chronic hepatitis B. (a) Contrast-enhanced transverse spoiled gradient-recalled-echo MR image obtained before ablation shows two hypervascular lesions in segments V (black arrow) and VI (white arrow). (b) Contrast-enhanced transverse CT image obtained 3 weeks after ablation shows hypoattenuating, nonenhancing coagulation defects at the treatment sites (arrows) with no abnormal nodular enhancement suggesting residual tumor. (c) Histologic slice (hematoxylin-eosin stain; original magnification, x400) of tumor in segment VI demonstrates complete necrosis, marked by homogeneous hypereosinophilic cytoplasm and loss of normal nuclear elements. (d) Histologic slice (hematoxylin-eosin stain; original magnification, x20) of lesion in segment V shows necrotic areas (*) with bordering regions of viable-appearing tumor to the right. Viability was confirmed with findings from higher magnification.

View larger version (175K): [in a new window]   Figure d. Images of a 33-year-old man with chronic hepatitis B. (a) Contrast-enhanced transverse spoiled gradient-recalled-echo MR image obtained before ablation shows two hypervascular lesions in segments V (black arrow) and VI (white arrow). (b) Contrast-enhanced transverse CT image obtained 3 weeks after ablation shows hypoattenuating, nonenhancing coagulation defects at the treatment sites (arrows) with no abnormal nodular enhancement suggesting residual tumor. (c) Histologic slice (hematoxylin-eosin stain; original magnification, x400) of tumor in segment VI demonstrates complete necrosis, marked by homogeneous hypereosinophilic cytoplasm and loss of normal nuclear elements. (d) Histologic slice (hematoxylin-eosin stain; original magnification, x20) of lesion in segment V shows necrotic areas (*) with bordering regions of viable-appearing tumor to the right. Viability was confirmed with findings from higher magnification.