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Reading Protocol for Dynamic Contrast-enhanced MR Images of the Breast: Sensitivity and Specificity Analysis¹

¹ From the Department of Radiology, Addenbrooke's Hospital, Cambridge, England (R.M.L.W.); Study Coordinating Office, Section of Magnetic Resonance, Institute of Cancer Research, Royal Marsden Hospital, Downs Rd, Sutton, Surrey SM2 5PT, England (L.P., R.H., M.O.L.); Department of Radiology, University of Aberdeen, Scotland (F.J.G.); CR-UK Genetic Epidemiology Unit, Cambridge, England (D.T., D.E.); Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Royal Marsden Hospital, London, England (S.R.L.); and Paul Strickland Scanner Centre, Mount Vernon Hospital, Northwood, Middlesex, England (A.P.). Received April 23, 2004; revision requested July 1; revision received October 19; accepted December 10. Supported by a project grant from the UK Medical Research Council. Address correspondence to M.O.L. (e-mail: martin.leach{at}icr.ac.uk).

View larger version (19K): [in a new window]   Figure a. (a) Graph of proportion of cases in which a lesion was analyzed plotted against the number of months the radiologist had worked for the study. Graph shows that the number of lesions diminished steadily with the amount of time the radiologist participated in the study. This may be due to the radiologists having concerns that enhancing highlights in premenopausal women may be clinically important lesions. With more experience, they were confident to regard these bright lesions as physiologic hormonal contrast enhancement and therefore normal (19). (b) Graph of number of recordings of ROIs in cases in which a lesion was analyzed, plotted against the number of months the radiologist has worked for the study. Graph shows that with more time participating in the study, radiologists became more confident to analyze one ROI than they were initially.

View larger version (18K): [in a new window]   Figure b. (a) Graph of proportion of cases in which a lesion was analyzed plotted against the number of months the radiologist had worked for the study. Graph shows that the number of lesions diminished steadily with the amount of time the radiologist participated in the study. This may be due to the radiologists having concerns that enhancing highlights in premenopausal women may be clinically important lesions. With more experience, they were confident to regard these bright lesions as physiologic hormonal contrast enhancement and therefore normal (19). (b) Graph of number of recordings of ROIs in cases in which a lesion was analyzed, plotted against the number of months the radiologist has worked for the study. Graph shows that with more time participating in the study, radiologists became more confident to analyze one ROI than they were initially.

View larger version (52K): [in a new window]   Figure B1. Worksheet 1.

View larger version (50K): [in a new window]   Figure B2. Worksheet 2.