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Screening with Multisection CT: Unmasking the Benefit¹

¹ From the Department of Quantitative Health Sciences (N.A.O.) and Division of Radiology (N.A.O., M.T.M.), the Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195. Received February 1, 2005; revision requested February 14; revision received February 19; accepted March 7. Address correspondence to N.A.O. (e-mail: nobuchow{at}bio.ri.ccf.org).

View larger version (24K): [in a new window]   Figure 1. Graph shows the effect of the sensitivity level on the absolute risk reduction due to screening (left vertical axis) and on the number of people who must be screened to save one life (right vertical axis), with consideration of three values for change in the fatality rate (0.10, 0.40, and 0.70) when disease is detected clinically versus preclinically. As sensitivity increases, the absolute risk reduction due to screening also increases, and the number who must be screened to save one life decreases.

View larger version (16K): [in a new window]   Figure 2. Graph shows changes in sensitivity (vertical axis) and false-positive rate (horizontal axis) according to the number of independent readings of an image series: one (1), two (2), or three (3). Image interpretation by a series of readers (in which images interpreted as negative for disease at the initial reading are passed to another reader) increases sensitivity and the false-positive rate.