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Computer-aided Diagnosis of Localized Ground-Glass Opacity in the Lung at CT: Initial Experience¹

¹ From the Department of Radiology, Seoul National University College of Medicine, and the Institute of Radiation Medicine, SNUMRC, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea (K.G.K., J.M.G., J.H.K., H.J.L., J.G.I.); Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Korea (B.G.M.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (K.T.B.). Received August 23, 2004; revision requested October 28; revision received November 19; accepted December 24. Supported in part by Seoul National University Hospital Research Grant (0420030300) and by a grant from the Korea Health 21 Research and Development Project-Ministry of Health and Welfare, Republic of Korea (03-PJ1-PG10-51300-0006). Address correspondence to J.M.G. (e-mail: jmgoo{at}plaza.snu.ac.kr).

View larger version (15K): [in a new window]   Figure 1. Graph depicts ROC curve of neural network for classification of GGO ROIs and non-GGO ROIs. Az = 0.92.

View larger version (103K): [in a new window]   Figure 2a. CT scans obtained with threshold of 0.9 demonstrate true-positive, true-negative, false-positive, and false-negative findings. (a) Transverse CT scan in 69-year-old woman shows true-positive finding (arrow) in right middle lobe. Although dependent opacity (arrowheads) can be categorized as GGO according to attenuation, these areas were correctly classified as negative (true-negative finding). (b) Transverse CT scan in 69-year-old woman shows localized GGO (arrow) in right upper lobe that was not detected (false-negative finding). (c) Transverse CT scan in 73-year-old woman shows false-positive finding (arrow) near airways and vessel. Arrowhead indicates true-positive finding. (d) Transverse CT scan in 61-year-old woman shows true-positive finding (arrow) in left upper lobe. Arrowheads indicate false-positive finding that was caused by artifact.

View larger version (78K): [in a new window]   Figure 2b. CT scans obtained with threshold of 0.9 demonstrate true-positive, true-negative, false-positive, and false-negative findings. (a) Transverse CT scan in 69-year-old woman shows true-positive finding (arrow) in right middle lobe. Although dependent opacity (arrowheads) can be categorized as GGO according to attenuation, these areas were correctly classified as negative (true-negative finding). (b) Transverse CT scan in 69-year-old woman shows localized GGO (arrow) in right upper lobe that was not detected (false-negative finding). (c) Transverse CT scan in 73-year-old woman shows false-positive finding (arrow) near airways and vessel. Arrowhead indicates true-positive finding. (d) Transverse CT scan in 61-year-old woman shows true-positive finding (arrow) in left upper lobe. Arrowheads indicate false-positive finding that was caused by artifact.

View larger version (110K): [in a new window]   Figure 2c. CT scans obtained with threshold of 0.9 demonstrate true-positive, true-negative, false-positive, and false-negative findings. (a) Transverse CT scan in 69-year-old woman shows true-positive finding (arrow) in right middle lobe. Although dependent opacity (arrowheads) can be categorized as GGO according to attenuation, these areas were correctly classified as negative (true-negative finding). (b) Transverse CT scan in 69-year-old woman shows localized GGO (arrow) in right upper lobe that was not detected (false-negative finding). (c) Transverse CT scan in 73-year-old woman shows false-positive finding (arrow) near airways and vessel. Arrowhead indicates true-positive finding. (d) Transverse CT scan in 61-year-old woman shows true-positive finding (arrow) in left upper lobe. Arrowheads indicate false-positive finding that was caused by artifact.

View larger version (75K): [in a new window]   Figure 2d. CT scans obtained with threshold of 0.9 demonstrate true-positive, true-negative, false-positive, and false-negative findings. (a) Transverse CT scan in 69-year-old woman shows true-positive finding (arrow) in right middle lobe. Although dependent opacity (arrowheads) can be categorized as GGO according to attenuation, these areas were correctly classified as negative (true-negative finding). (b) Transverse CT scan in 69-year-old woman shows localized GGO (arrow) in right upper lobe that was not detected (false-negative finding). (c) Transverse CT scan in 73-year-old woman shows false-positive finding (arrow) near airways and vessel. Arrowhead indicates true-positive finding. (d) Transverse CT scan in 61-year-old woman shows true-positive finding (arrow) in left upper lobe. Arrowheads indicate false-positive finding that was caused by artifact.