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DOI: 10.1148/radiol.2382032065
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Three-dimensional Fast-Recovery Fast Spin-Echo MRCP: Comparison with Two-dimensional Single-Shot Fast Spin-Echo Techniques1

Aaron Sodickson, MD, PhD, Koenraad J. Mortele, MD, Matthew A. Barish, MD, Kelly H. Zou, PhD, Steven Thibodeau, BS, RT and Clare M. C. Tempany, MD

1 From the Department of Radiology (A.S., K.H.Z., S.T.), Division of Abdominal Imaging and Intervention (K.J.M., M.A.B., C.M.C.T.), Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115; and Department of Health Care Policy, Harvard Medical School, Boston, Mass (K.H.Z.). Received December 18, 2003; revision requested February 20, 2004; revision received February 22, 2005; accepted March 17; final version accepted May 2. Address correspondence to A.S. (e-mail: asodickson{at}partners.org).


Figure 1
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Figure 1a: Sample MR images in patient with normal-caliber biliary tree demonstrate small branches (arrow) of the right hepatic duct. The pancreatic duct (arrowheads) is mildly distended and displaced around a duodenal diverticulum (*). (a) Coronal 2D SSFSE thin-section image ({infty}/800, 3-mm-thick sections) and (b) corresponding coronal 3D FRFSE image (1500/480, 4-mm-thick sections interpolated to 2 mm). (c) Oblique coronal 2D SSFSE thick-slab image ({infty}/900, 40-mm-thick slab) and (d) oblique coronal MIP reconstruction from the 3D FRFSE data.

 

Figure 1
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Figure 1b: Sample MR images in patient with normal-caliber biliary tree demonstrate small branches (arrow) of the right hepatic duct. The pancreatic duct (arrowheads) is mildly distended and displaced around a duodenal diverticulum (*). (a) Coronal 2D SSFSE thin-section image ({infty}/800, 3-mm-thick sections) and (b) corresponding coronal 3D FRFSE image (1500/480, 4-mm-thick sections interpolated to 2 mm). (c) Oblique coronal 2D SSFSE thick-slab image ({infty}/900, 40-mm-thick slab) and (d) oblique coronal MIP reconstruction from the 3D FRFSE data.

 

Figure 1
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Figure 1c: Sample MR images in patient with normal-caliber biliary tree demonstrate small branches (arrow) of the right hepatic duct. The pancreatic duct (arrowheads) is mildly distended and displaced around a duodenal diverticulum (*). (a) Coronal 2D SSFSE thin-section image ({infty}/800, 3-mm-thick sections) and (b) corresponding coronal 3D FRFSE image (1500/480, 4-mm-thick sections interpolated to 2 mm). (c) Oblique coronal 2D SSFSE thick-slab image ({infty}/900, 40-mm-thick slab) and (d) oblique coronal MIP reconstruction from the 3D FRFSE data.

 

Figure 1
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Figure 1d: Sample MR images in patient with normal-caliber biliary tree demonstrate small branches (arrow) of the right hepatic duct. The pancreatic duct (arrowheads) is mildly distended and displaced around a duodenal diverticulum (*). (a) Coronal 2D SSFSE thin-section image ({infty}/800, 3-mm-thick sections) and (b) corresponding coronal 3D FRFSE image (1500/480, 4-mm-thick sections interpolated to 2 mm). (c) Oblique coronal 2D SSFSE thick-slab image ({infty}/900, 40-mm-thick slab) and (d) oblique coronal MIP reconstruction from the 3D FRFSE data.

 

Figure 2
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Figure 2a: MR images of a Klatskin tumor. (a) Sequential thin-section coronal 2D SSFSE images ({infty}/800, 3-mm-thick sections) with horizontal line added for reference. Motion-related in-plane misregistration is evidenced by superior displacement of the biliary tree on the two right-hand images, whereas through-plane misregistration results in duplicate coverage of the same anatomic features (arrows) on the first and third images (although it is just as likely to fail to depict anatomic features). (b) Sequential source coronal 3D FRFSE images (1500/480, 4-mm-thick sections interpolated to 2 mm) demonstrate uniform image registration and spacing. (c) Example oblique coronal 2D SSFSE thick-slab images ({infty}/900, 40-mm-thick slab) and (d) corresponding MIP reconstructions from the 3D FRFSE data. Note improved visibility of the thin-caliber pancreatic duct (arrowheads) with the 2D versus the 3D technique. In d, ability to reconstruct images at any angle assists with evaluation of intrahepatic ductal invasion by cholangiocarcinoma because the right hepatic duct is clearly obstructed beyond its first-order intrahepatic confluence (arrow).

 

Figure 2
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Figure 2b: MR images of a Klatskin tumor. (a) Sequential thin-section coronal 2D SSFSE images ({infty}/800, 3-mm-thick sections) with horizontal line added for reference. Motion-related in-plane misregistration is evidenced by superior displacement of the biliary tree on the two right-hand images, whereas through-plane misregistration results in duplicate coverage of the same anatomic features (arrows) on the first and third images (although it is just as likely to fail to depict anatomic features). (b) Sequential source coronal 3D FRFSE images (1500/480, 4-mm-thick sections interpolated to 2 mm) demonstrate uniform image registration and spacing. (c) Example oblique coronal 2D SSFSE thick-slab images ({infty}/900, 40-mm-thick slab) and (d) corresponding MIP reconstructions from the 3D FRFSE data. Note improved visibility of the thin-caliber pancreatic duct (arrowheads) with the 2D versus the 3D technique. In d, ability to reconstruct images at any angle assists with evaluation of intrahepatic ductal invasion by cholangiocarcinoma because the right hepatic duct is clearly obstructed beyond its first-order intrahepatic confluence (arrow).

 

Figure 2
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Figure 2c: MR images of a Klatskin tumor. (a) Sequential thin-section coronal 2D SSFSE images ({infty}/800, 3-mm-thick sections) with horizontal line added for reference. Motion-related in-plane misregistration is evidenced by superior displacement of the biliary tree on the two right-hand images, whereas through-plane misregistration results in duplicate coverage of the same anatomic features (arrows) on the first and third images (although it is just as likely to fail to depict anatomic features). (b) Sequential source coronal 3D FRFSE images (1500/480, 4-mm-thick sections interpolated to 2 mm) demonstrate uniform image registration and spacing. (c) Example oblique coronal 2D SSFSE thick-slab images ({infty}/900, 40-mm-thick slab) and (d) corresponding MIP reconstructions from the 3D FRFSE data. Note improved visibility of the thin-caliber pancreatic duct (arrowheads) with the 2D versus the 3D technique. In d, ability to reconstruct images at any angle assists with evaluation of intrahepatic ductal invasion by cholangiocarcinoma because the right hepatic duct is clearly obstructed beyond its first-order intrahepatic confluence (arrow).

 

Figure 2
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Figure 2d: MR images of a Klatskin tumor. (a) Sequential thin-section coronal 2D SSFSE images ({infty}/800, 3-mm-thick sections) with horizontal line added for reference. Motion-related in-plane misregistration is evidenced by superior displacement of the biliary tree on the two right-hand images, whereas through-plane misregistration results in duplicate coverage of the same anatomic features (arrows) on the first and third images (although it is just as likely to fail to depict anatomic features). (b) Sequential source coronal 3D FRFSE images (1500/480, 4-mm-thick sections interpolated to 2 mm) demonstrate uniform image registration and spacing. (c) Example oblique coronal 2D SSFSE thick-slab images ({infty}/900, 40-mm-thick slab) and (d) corresponding MIP reconstructions from the 3D FRFSE data. Note improved visibility of the thin-caliber pancreatic duct (arrowheads) with the 2D versus the 3D technique. In d, ability to reconstruct images at any angle assists with evaluation of intrahepatic ductal invasion by cholangiocarcinoma because the right hepatic duct is clearly obstructed beyond its first-order intrahepatic confluence (arrow).

 

Figure 3
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Figure 3: Graph shows technical quality grades for thin-section 2D SSFSE versus coronal 3D FRFSE imaging (2D thin vs 3D) and thick-slab 2D SSFSE imaging versus 3D FRFSE rotating MIP reconstruction (2D thick vs MIP). 3D > 2D = technical quality greater with the 3D technique, 2D > 3D = quality was greater with the 2D technique. The denominator for determining percentages was 53 studies. For both readers and both comparison arms there is a significant improvement in technical quality with 3D FRFSE compared with 2D SSFSE. Mean grade differences and P values were calculated with paired Student t test.

 

Figure 4
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Figure 4: Graph shows duct visibility with thin-section 2D SSFSE versus 3D FRFSE imaging. For each anatomic segment, bar graph shows the percentage of 3D studies with higher (3D > 2D) and lower (2D > 3D) visibility scores than the 2D studies. The last column shows values for all anatomic segments combined. Results from reader A (left) and reader B (right) are in each column. The absence of gray bars for the right hepatic duct (RHD), left hepatic duct (LHD), and common hepatic duct (CHD) segments indicates that there were no such grade differences in those segments. The tabular portion shows corresponding mean grade difference and P value (paired Student t test) for each reader. CBD = common bile duct, CD = cystic duct, PB = pancreatic body, PH = pancreatic head, PT = pancreatic tail.

 

Figure 5
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Figure 5: Graph shows duct visibility with thick-slab 2D SSFSE imaging versus 3D FRFSE rotating MIP reconstruction. For each anatomic segment, bar graph shows the percentage of 3D studies with higher (3D > 2D) and lower (2D > 3D) visibility scores than the 2D studies. The last column shows values for all anatomic segments combined. Within each column, results from reader A are on the left and those from reader B are on the right. The absence of a gray bar for reader A in the common bile duct segment indicates that there was no such grade difference in this segment. The tabular portion shows corresponding mean grade difference and P value (paired Student t test) for each reader. See Figure 4 for abbreviations.

 

Figure 6
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Figure 6: Graph shows total visualized segments per patient for thin-section 2D SSFSE versus coronal 3D FRFSE imaging (2D thin vs 3D coronal) and thick-slab 2D SSFSE imaging versus 3D FRFSE rotating MIP reconstruction (2D thick vs 3D MIP). Bar graph shows the excess number of segments visualized per patient with the 3D technique over the corresponding 2D technique (negative numbers indicate greater number of segments visualized with 2D technique vs 3D technique). Two separate visibility threshold criteria were used for each reader and comparison arm: segments that were fully visualized and segments that were either fully or partially visualized. The table beneath each set of bars shows the average number of segments visualized with each technique, difference in number of visualized segments, and P values (Student t test).

 

Figure 7
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Figure 7: Graph shows total number of visualized segments per patient after exclusion of nondiagnostic studies (poor or unreadable technical quality); only diagnostic studies of excellent, slightly limited, and marginal quality were included. Data are for thin-section 2D SSFSE versus coronal 3D FRFSE imaging (2D thin vs 3D coronal) and thick-slab 2D SSFSE imaging versus 3D FRFSE rotating MIP reconstruction (2D thick vs 3D MIP). Bar graph data are the excess number of segments visualized with the 3D technique over the corresponding 2D technique (negative numbers indicate greater number of segments visualized with 2D technique vs 3D technique). Two separate visibility threshold criteria were used for each reader and comparison arm: segments that were fully visualized and segments that were either fully or partially visualized. Corresponding P values (Student t test) are beneath each bar.

 

Figure 8
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Figure 8: Graph shows interobserver agreement ({kappa} and percentage agreement) between the two readers. Data were calculated from visibility grades of all pooled anatomic segments for each of the four pulse sequences. 2D thick = thick-slab 2D SSFSE, 2D thin = thin-section 2D SSFSE, 3D coronal = coronal 3D FRFSE, 3D MIP = 3D FRFSE MIP reconstruction.

 





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