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Figure 5a. Primary tumor stage pT2N1G3 in a 39-year-old patient. (a) Coronal USPIO-enhanced MR images (left: T1-weighted SE 450/8; middle: fat-saturated T2-weighted fast SE 4,500/36; right: T1-weighted fast spoiled GRE 80/8 with a 40° flip angle) show a round node (arrowheads) with a size of 1.4 x 0.9 cm. The node is hyperintense on the T2-weighted image and shows only a small peripheral rim of USPIO enhancement. It was thus classified as malignant. An adjacent node (arrows) showed heterogeneous but strong USPIO enhancement and was falsely diagnosed as benign. (b) Photomicrograph of a histologic specimen of one metastatic lymph node. Arrowheads indicate small foci of metastatic tissue. Inset shows metastatic focus. (Hematoxylin-eosin stain; original magnification, x12; inset original magnification, x100.)