View larger version (260K)

Figure 3a. Benign-appearing calcifications that could be easily overlooked, rated as BI-RADS category 2 at unblinded review and recalled by no radiologists at blinded review. Magnification of (a) craniocaudal and (b) mediolateral oblique mammograms in a 69-year-old woman show three benign-appearing calcifications (arrows). Fourteen months later, (c) craniocaudal and (d) mediolateral oblique mammograms show a 4-mm cluster of pleomorphic calcifications (arrows) in the same location. Biopsy results indicated DCIS with an intermediate grade.